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Phân tích hàm lượng selen (Se) trong móng chân bệnh nhân ung thư đại trực tràng

Huỳnh Trúc Phương, Trần Tuấn Anh, Nguyễn Văn Hạnh, Nguyễn Thị Trúc Linh, Trương Thị Hồng Loan, Hồ Mạnh Dũng, Nguyễn Văn Đông, Đinh Thanh Bình

Tạp chí Phát triển Khoa học và Công nghệ – Khoa học Tự nhiên, 5(1):969-974

Tóm tắt:

Selenium (Se) là nguyên tố vết có vai trò quan trọng trong các chức năng sinh học của cơ thể con người. Móng chân được xem như là vật liệu thích hợp cho việc tìm ra mối liên hệ giữa hàm lượng nguyên tố vết với bệnh tật ở con người. Mục tiêu của nghiên cứu này là phân tích và đánh giá hàm lượng Se trong móng chân của bệnh nhân ung thư đại trực tràng nhằm tìm ra nguy cơ ung thư ở con người. Hàm lượng Se trong móng chân của 60 bệnh nhân ung thư đại trực tràng (nam giới chiếm 63,3%) và 22 người bình thường (nam giới chiếm 54,5%) được phân tích bằng phương pháp chuẩn hóa k0 trong kỹ thuật phân tích kích hoạt neutron dụng cụ (k0-INAA). Kết quả của phép phân tích cho thấy hàm lượng Se đối với người bình thường là 1,13 μg/g và 1,32 μg/g tương ứng với nam giới và nữ giới; đối với bệnh nhân ung thư đại tràng là 0,70 μg/g và 0,84 μg/g tương ứng với nam giới và nữ giới; đối với bệnh nhân ung thư trực tràng là 0,86 μ g/g và 0,82 μ g/g tương ứng với nam giới và nữ giới. Bằng phép phân tích thống kê nghiên cứu này cho thấy rằng hàm lượng Se trong móng chân có sự khác biệt đáng kể giữa bệnh nhân và người bình thường (p <0,05), nhưng không có sự khác biệt đáng kể giữa nữ giới và nam giới. Kết luận của nghiên cứu này là móng chân của các bệnh nhân ung thư đại trực tràng có hàm hượng Se thấp hơn so với người bình thường.

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Optimization of uranium separation using silica gel impregnated tri‐n‐butyl phosphate for alpha spectrometry analysis of soil samples

Van Thang Nguyen, Xuan Son Vi, Nguyen Phong Thu Huynh, Cong Hao Le

Abstract:

Silica gel impregnated tri-n-butyl phosphate was used as a chromatography column for extraction of uranium radioisotopes from soil samples. Diluted HNO3 and H2SO4 were used as the mobile and striping phases, respectively. In these stages, concentrations of HNO3 and H2SO4 solutions for the uranium extraction yield were optimized. We found that 5 M HNO3 and 3 M H2SO4 were the best solutions for uranium separation. Effects of electrodeposition conditions on uranium deposition yield were considered. Results showed that current of 1.5 mA, deposition time of 75 min, pH 2 and electrode gap of 1.5 cm were optimal conditions for electrodeposition.

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Optimization of the Entropy-Based Wavelet Method for Removing Strong RF and AC Interferences in a Charge Detection Linear Ion Trap Mass Spectrometer

Minh Cong Dang, Avinash A. Patil, Thị Khánh Ly Lại, Szu-Wei Chou, Trang Kieu Thi Hoang, Mhar Ian Cua Estayan, and Wen-Ping Peng

Analytical Chemistry 2025 97 (9), 5066-5076

Abstract:

We developed an entropy-based wavelet method to effectively remove interference from strong radio frequency (RF) and auxiliary alternating current (AC) fields in a linear ion trap (LIT) mass spectrometer coupled to a charge sensing particle detector (CSPD). By optimizing the energy-to-Shannon entropy, we identified the optimal mother wavelet family and decomposition level and determined suitable threshold values based on the median of sub-band coefficients at each decomposition level. These thresholds were applied as rigid criteria across all decomposition levels to eliminate noise interferences and avoid the arbitrary choice of the threshold. This entropy wavelet-based method successfully denoised high-mass protein mass spectra, achieving significant improvements in signal-to-noise ratio (S/N) for immunoglobulin G (IgG) and alpha-2 macroglobulin (A2M) ions, with increases of 68.03% and 81.73%, respectively. Our method surpasses previously reported baseline correction techniques, such as orthogonal wavelet packet decomposition (OWPD) filtering, and enhances the
sensitivity of LIT mass spectrometry (LIT-MS) in analyzing high-mass protein ions.

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Le Thi Ngoc Trang, Huynh Dinh Chuong, Tran Thien Thanh

Journal of Radioanalytical and Nuclear Chemistry (2020)

Abstract:

In this study, the optimization of the p-type HPGe detector model has been performed to improve the accuracy of Monte Carlo simulation in calculating full energy peak efficiency. The optimized detector model was validated by comparison of simulated efficiencies with experimental efficiencies for measurement configurations of point-like sources at various distances from the detector surface and cylindrical sources on the detector surface. The obtained results showed an excellent agreement between the simulated and experimental efficiencies with relative deviations of less than 4% in the energy range from 53 to 1847 keV.

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Onset of collectivity for argon isotopes close to $N = 32$

B. D. Linh et al.

Phys. Rev. C 109, 034312

Abstract:

The shell closure at $N = 32$ has been investigated by a first spectroscopy of the $N = 31$ nucleus $49 Ar$ at the Radioactive Isotope Beam Factory. Using the $50 Ar (p, p n)$ reaction channel in inverse kinematics, $50 Ar$ projectiles at 217 MeV/nucleon impinged on a 150 mm long liquid hydrogen target, part of the MINOS device. Prompt deexcitation $γ$ rays were measured with the NaI(Tl) array ${DALI 2}^{+}$ . Reaction products were analyzed with the SAMURAI spectrometer, which allowed the measurement of the momentum distributions and angular momentum transfer. Data were compared to state-of-the-art theoretical predictions, including shell-model, energy-density functional, and ab initio calculations. An onset of collectivity is suggested besides the spherical configuration typical of a closed shell nucleus, such as for $52 Ca$ .

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On the Bohr-Sommerfeld quantization condition and assault frequency in a semiclassical model for α decay

Le Hoang Chien, Nguyen Tri Toan Phuc

Nuclear Physics A 1018 (2022) 122373

Abstract:

We study the impacts of the Bohr-Sommerfeld quantization condition and the assault frequency on the α decay half-life within the semiclassical model. The potential between the α particle and daughter nucleus is calculated by the double-folding model using the CDM3Y3 density-dependent nucleon-nucleon interaction with a finite-range exchange term. We show that the proper implementation of the Bohr-Sommerfeld condition leads to a considerable change of the calculated α decay half-life with certain forms of potential. We also propose an alternative treatment for the assault frequency based on the generalized oscillator potential. This description of assault frequency considerably improves the agreement between the calculated α decay half-lives and the experimental data.

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FACULTY OF PHYSICS & ENGINEERING PHYSICS

DEPARTMENT OF NUCLEAR PHYSICS - NUCLEAR ENGINEERING - MEDICAL PHYSICS

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